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首页> 外文OA文献 >Reduced sympathetic innervation after alteration of target cell neurotransmitter phenotype in transgenic mice.
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Reduced sympathetic innervation after alteration of target cell neurotransmitter phenotype in transgenic mice.

机译：转基因小鼠中靶细胞神经递质表型改变后的交感神经减少。

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Neurotransmitters play a variety of important roles during nervous system development. In the present study, we hypothesized that neurotransmitter phenotype of both projecting and target cells is an important factor for the final synaptic linkage and its specificity. To test this hypothesis, we used transgenic techniques to convert serotonin/melatonin-producing cells of the pineal gland into cells that also produce dopamine and investigated the innervation of the phenotypically altered target cells. This phenotypic alteration markedly reduced the noradrenergic innervation originating from the superior cervical ganglia. Although the mechanism by which the reduction occurs is presently unknown, quantitative enzyme-linked immunoassay showed the presence of the equivalent amounts of nerve growth factor (NGF) in the control and transgenic pineal glands, suggesting that it occurred in a NGF-independent manner. The results suggest that target neurotransmitter phenotype influences the formation of afferent connections during development.
机译：神经递质在神经系统发育过程中起着多种重要作用。在本研究中，我们假设投射细胞和靶细胞的神经递质表型是最终突触连接及其特异性的重要因素。为了验证这一假设，我们使用转基因技术将松果体中分泌5-羟色胺/褪黑激素的细胞转化为也产生多巴胺的细胞，并研究了表型改变的靶细胞的神经支配。这种表型改变显着减少了源自上颈神经节的去甲肾上腺素能神经支配。尽管目前尚不清楚还原发生的机理，但定量酶联免疫测定显示对照和转基因松果体中存在等量的神经生长因子（NGF），这表明它以NGF无关的方式发生。结果表明目标神经递质表型影响发育过程中传入连接的形成。

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